Mindfulness and Cognition in Schizophrenia

Not Applicable

Terminated

• Conditions: Schizophrenia
• Interventions: Behavioral: Mindfulness

• Registration Number: NCT03318640
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Mindfulness (innovative and integrative practice in care) allows the individual to adapt his/her behavior (physical and emotional), in a stressful environment, by regulating cardiac activity, especially the parasympathetic system. In schizophrenia, despite the positive effect of treatments on symptoms (delusions and hallucinations), patients have altered markers of the parasympathetic (high frequency, HF) system. The investigator propose a session of Mindfulness Based Stress Reduction (MBSR) for patients suffering from schizophrenia in order to measure the impact on the parasympathetic system (HF), self-awareness (being well in one's body and being aware of their own actions; EASE) and cognition (attention) in relation to the management of conflicts or emotions. The study compare with patients who receive a session of techniques based on the management of emotions and social cognition (cinemotion, Michael's Game and Tom Remed).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-19
• Study First Submitted QC: 2017-10-23
• Study First Posted: 2017-10-24
• Study Start: 2018-09-11
• Primary Completion: 2021-05-03
• Study Completion: 2021-07-12
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-12
• Last Update Posted: 2023-12-18

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 34

Inclusion Criteria

• DSM-IV diagnosis of schizophrenia (men only)
• aged 18-55
• with no change in antipsychotic medication and clinical status within four weeks prior to the study
• affiliates or entitled to a social security scheme
• who have given their informed consent before participating in the study.

Exclusion Criteria

• History of head trauma, neurological disease or not stabilized serious physical illness
• Disorders related to the use of a psychoactive substance, as defined by the DSM-IV (abuse, dependence or withdrawal) within 6 months
• Beta blocking and anti-arrhythmic medications.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mindfulness	Mindfulness	Patient will have 8 sessions (1h30) of mindfulness based on Kabat-Zinn program during one month.

Primary Outcome Measures

Name	Time	Method
High Frequency spectral power	2 months	High Frequency spectral power

Secondary Outcome Measures

Name	Time	Method
Score	2 months	The five facet questionnaire Mindfulness Questionary Freiburg

Trial Locations

Locations (1)

CHU Saint Etienne; 🇫🇷 Saint-Étienne, France