Effect of Mindfulness (MBSR) on the Parasympathetic System and Cognition in Schizophrenia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- High Frequency spectral power
Study Overview
Brief Summary
Mindfulness (innovative and integrative practice in care) allows the individual to adapt his/her behavior (physical and emotional), in a stressful environment, by regulating cardiac activity, especially the parasympathetic system. In schizophrenia, despite the positive effect of treatments on symptoms (delusions and hallucinations), patients have altered markers of the parasympathetic (high frequency, HF) system. The investigator propose a session of Mindfulness Based Stress Reduction (MBSR) for patients suffering from schizophrenia in order to measure the impact on the parasympathetic system (HF), self-awareness (being well in one's body and being aware of their own actions; EASE) and cognition (attention) in relation to the management of conflicts or emotions. The study compare with patients who receive a session of techniques based on the management of emotions and social cognition (cinemotion, Michael's Game and Tom Remed).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •DSM-IV diagnosis of schizophrenia (men only)
- •aged 18-55
- •with no change in antipsychotic medication and clinical status within four weeks prior to the study
- •affiliates or entitled to a social security scheme
- •who have given their informed consent before participating in the study.
Exclusion Criteria
- •History of head trauma, neurological disease or not stabilized serious physical illness
- •Disorders related to the use of a psychoactive substance, as defined by the DSM-IV (abuse, dependence or withdrawal) within 6 months
- •Beta blocking and anti-arrhythmic medications.
Arms & Interventions
Mindfulness
Patient will have 8 sessions (1h30) of mindfulness based on Kabat-Zinn program during one month.
Intervention: Mindfulness (Behavioral)
Control
Patient will have usual medical care.
Outcomes
Primary Outcomes
High Frequency spectral power
Time Frame: 2 months
High Frequency spectral power
Secondary Outcomes
- Score(2 months)