Early wound healing parameters, cytokines and MMPs and their progressive course after subgingival debridement in chronic periodontitis. A pilot study - Progression of early wound healing parameters, cytokines and MMPs

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年5月13日

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•Patients maybe former smokers not consuming more than 5 cigarettes a day.
•Periodontitis patients, diagnosed with chronic periodontitis, not having experienced a subgingival cleaning/debridement at least one year before baseline of the study. Patients should have at least four maxillary teeth with probing pocket depth greater or equal 4mm. Also implants that are present are included. If affected teeth are endodontically treated clinical or radiographic analysis should resemble a successful endodontic treated tooth. Patients should be healthy except the diagnosis of chronic periodontitis. This excludes patients suffering from high blood pressure, other systemic diseases that might interfere with the distinction of blood, saliva or intrasulcular parameters. Patients forced to take prophylactic antibiotics before treatment are also excluded. Patients should not have any antiobiotic medication after six months before the start of the study.

•Patients that are confirmed as heavy smokers are excluded. Therefore only former smokers (less or equal 5 cigarettes/day) are included in the study. Patients with systemic diseases, need for antiobiotic prophylaxis before treatment, patients with antibiotic treatment because of other reasons in the time interval of not more than 6 months before study start are also excluded. Further exclusion criteria is the receiving of a subgingival debridement shortly before baseline (less than one year).

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niversitair Medisch Centrum Sint Radboud