Outcome of Hydrocortisone,Ascorboc Acid and Thiamine therapy in patients of Severe Acute Malnutrition with Sepsis or Septic shock.
概览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- Amulya Pandey
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Outcome of Hydrocortisone Ascorbic Acid and thiamine therapy in patients of sam with sepsis /septic shock.
概览
简要总结
this hospital based randomised controlled trial aims to evaluate the effectiveness of intervention in children admitted to picu and wards.the primary outcome will be improvement in ,main clinical parameter e.g., oxygenation,ionotrope requirement, vitals and phoenix sepsis score.Secondary outcomes include assessment of adverse effects ,duration of hospital stay, need for mechanical ventilation and mortality.the study will be conducted over 1.5years AT GANDHI MEMORIAL HOSPITAL ,rewa.Eligible participants will be randomised into intervention and control groups.data will be analysed to determine both efficacy and safety of intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 29.00 Day(s) 至 5.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients Fulfilling the Sam Criteria of weight by height less than 3 standard deviation ,Mid upper arm circumference less than 115cm or Bilateral Pedal Oedema.
排除标准
- •Renal Failure ,Hepatic Failure ,other causes of Shock (hypovolemic,haemorrhagic,cardioigenic and neurogenic),Metabolic disorders,Chemotherapy/Steroid Therapy patients.
结局指标
主要结局
Outcome of Hydrocortisone Ascorbic Acid and thiamine therapy in patients of sam with sepsis /septic shock.
时间窗: At 0 ,3 and 7 days after admission.
Pheonix sepsis score and fss score assessed.
时间窗: At 0 ,3 and 7 days after admission.
次要结局
- Effectiveness of HAT therapy in recovery from septic shock assessed in terms of(Number and duration of inotrope requirement)
研究者
AMULYA PANDEY
shyam shah medical college