Metabolism of Lipids in Advanced Cancer
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Rate of hepatic de novo lipogenesis
研究概览
简要总结
The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
详细描述
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids
- •Recent weight loss
- •Advanced stage lung cancer (Stage 3 or 4)
排除标准
- •Having symptoms that may affect measures of fat metabolism (nausea, vomiting, problems swallowing, etc.)
- •Taking n-3 fatty acid supplements such as fish oil
结局指标
主要结局
Rate of hepatic de novo lipogenesis
时间窗: 9 months
次要结局
- Measures of fat transport and availability(9 months)
- Resting metabolic rate & fat oxidation(9 months)