Calculation of Normal MUNIX Variation in an Healthy Population
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 120
- Locations
- 2
- Primary Endpoint
- MUNIX
Study Overview
Brief Summary
Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject.
Our objective is to calculate normal variation of MUNIX in 4 muscles : tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation
Detailed Description
Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject.
Our objective is to calculate normal variation of MUNIX in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy subjects without neuromuscular disoreders or others diseases which can interfer with MUNIX measurement
- •More than 18 years old
Exclusion Criteria
- •Less than 18 years old
- •Diseases which can interfer with MUNIX measurement
Arms & Interventions
Healthy group
healthy subjects MUNIX will be performed
Intervention: MUNIX (Other)
Outcomes
Primary Outcomes
MUNIX
Time Frame: 3 months
motor unit number inedx in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus
Secondary Outcomes
- CMAP amplitudes(3 months)
- MUSIX(3 months)