MUNIX Variability in Healthy Subjects

Not Applicable

• Conditions: Healthy
• Interventions: Other: MUNIX

• Registration Number: NCT03593265
• Lead Sponsor: Assistance Publique Hopitaux De Marseille

Brief Summary

Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject.

Our objective is to calculate normal variation of MUNIX in 4 muscles : tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation

Detailed Description

Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject.

Our objective is to calculate normal variation of MUNIX in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation

Study Timeline

• Status Verified: 2018-07
• Study First Submitted: 2018-07-10
• Study First Submitted QC: 2018-07-10
• Last Update Submitted: 2018-07-10
• Study First Posted: 2018-07-20
• Last Update Posted: 2018-07-20
• Study Start: 2018-09
• Primary Completion: 2019-09
• Study Completion: 2020-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Healthy subjects without neuromuscular disoreders or others diseases which can interfer with MUNIX measurement
• More than 18 years old

Exclusion Criteria

• Less than 18 years old
• Diseases which can interfer with MUNIX measurement

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy group	MUNIX	healthy subjects MUNIX will be performed

Primary Outcome Measures

Name	Time	Method
MUNIX	3 months	motor unit number inedx in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus

Secondary Outcome Measures

Name	Time	Method
CMAP amplitudes	3 months	the greatest possible amplitude
MUSIX	3 months	muscle size index

Trial Locations

Locations (1)

Assistance Publique Des Hopitaux de Marseille; 🇫🇷 Marseille, Paca, France