Effects of capsinoids on energy expenditure by brown adipose tissue in humans

Not Applicable

• Conditions: Healthy male volunteers

• Registration Number: JPRN-UMIN000006073
• Lead Sponsor: Tenshi College, School of Nursing and Nutrition, Department of Nutrition

Brief Summary

Whole-body energy expenditure (EE) after oral ingestion of capsinoids or placebo was measured for 2hr in 18 healthy male volunteers. Brown adipose tissue (BAT) activity was undetectable and high in 8 and 10 subjects, respectively. Resting EE of the BAT-positive group was 1,460 +/- 54 kcal/day (mean +/- SEM), not differing from that in the BAT-negative group (1,506 +/- 37 kcal/day). After oral ingestion of capsinoids, EE of the BAT-positive group increased in 0.5-1 hr by 3.6 +/- 0.6 kcal/hr, which was greater (P<0.01) than that of the BAT-negative group (0.4 +/- 0.9 kcal/hr). Placebo ingestion produced no significant change in both groups. Neither capsinoids nor placebo changed skin temperature in various regions including those close to BAT deposits. 1. 65th Annual Meeting of Japanese Society of Nutrition and Food Science (May 15, 2011, Tokyo), Abstract book, p.206

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2011-03-01
• Study Start: 2011-07-29
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 18

Inclusion Criteria

Not provided

Exclusion Criteria

Body mass index >=30

Study & Design

• Study Type: Interventional
• Study Design: Not specified