Effects of capsinoids on energy expenditure by brown adipose tissue in humans - Human brown adipose tissue and capsinoids

Whole-body energy expenditure (EE) after oral ingestion of capsinoids or placebo was measured for 2hr in 18 healthy male volunteers. Brown adipose tissue (BAT) activity was undetectable and high in 8 and 10 subjects, respectively. Resting EE of the BAT-positive group was 1,460 +/- 54 kcal/day (mean +/- SEM), not differing from that in the BAT-negative group (1,506 +/- 37 kcal/day). After oral ingestion of capsinoids, EE of the BAT-positive group increased in 0.5-1 hr by 3.6 +/- 0.6 kcal/hr, which was greater (P<0.01) than that of the BAT-negative group (0.4 +/- 0.9 kcal/hr). Placebo ingestion produced no significant change in both groups. Neither capsinoids nor placebo changed skin temperature in various regions including those close to BAT deposits. 1. 65th Annual Meeting of Japanese Society of Nutrition and Food Science (May 15, 2011, Tokyo), Abstract book, p.206