Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
- Conditions
- Influenza
- Registration Number
- NCT00965354
- Lead Sponsor
- Imperial College London
- Brief Summary
The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks of Influenza A. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.
- Detailed Description
Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood.
The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 131
- Any patient admitted to hospital with suspected or confirmed influenza infection
- Patients who do not give their consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways. 15 months Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (8)
Chelsea and Westminster Hospital NHS Foundation Trust
🇬🇧London, United Kingdom
Liverpool Women's NHS Foundation Trust
🇬🇧Liverpool, United Kingdom
Aintree Hospitals NHS Trust
🇬🇧Liverpool, United Kingdom
Royal Brompton and Harefield NHS Foundation Trust
🇬🇧London, United Kingdom
Imperial College Healthcare NHS Trust
🇬🇧London, United Kingdom
Alder Hey Children's Foundation NHS Trust
🇬🇧Liverpool, United Kingdom
Wirral University Teaching Hospital NHS Foundation Trust
🇬🇧Wirral, United Kingdom
Royal Liverpool University Hospital
🇬🇧Liverpool, United Kingdom