Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 8
- 主要终点
- Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways.
研究概览
简要总结
The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks of Influenza A. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.
详细描述
Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood.
The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient admitted to hospital with suspected or confirmed influenza infection
排除标准
- •Patients who do not give their consent
结局指标
主要结局
Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways.
时间窗: 15 months
Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages.
次要结局
未报告次要终点