Clinical Characteristics and Outcomes of Patients with Premature Acute Myocardial Infarction in Serbia - a Multicenter National Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 11
- 主要终点
- Incidence and Prevalence of AMI in Patients Aged ≤ 45 Years in Serbia
研究概览
简要总结
This observational multicentric national study aims to understand better acute myocardial infarction (heart attack) in young adults aged 45 years or younger in Serbia. By analyzing patient characteristics, medical history, test results, and treatment outcomes, the research seeks to identify factors contributing to heart attacks in this population and improve prevention and treatment strategies.
Participants will undergo routine tests during hospitalization, and specific blood samples will be collected for advanced analyses, including genetic testing. Follow-up will include periodic check-ins to monitor health outcomes.
The study will also explore differences in heart attack causes and outcomes in younger individuals compared to older populations, focusing on risk factors like smoking, cholesterol levels, and genetic predisposition.
Participation is voluntary, and all collected data will remain confidential.
详细描述
Study Overview This national, multicenter study combines retrospective and prospective analyses to investigate AMI in patients aged ≤ 45 years in Serbia. The primary aim is to characterize the clinical, demographic, and angiographic profiles of these patients, identify specific risk factors, and evaluate treatment outcomes. The findings aim to inform prevention, early diagnosis, and treatment strategies for premature AMI.
Objectives
Primary Objectives:
Determine the incidence and prevalence of AMI in this population. Analyze demographic characteristics and the prevalence of standard atherosclerotic risk factors (e.g., smoking, diabetes, hypertension, and socioeconomic status).
Examine angiographic findings, including obstructive or non-obstructive coronary artery disease and other abnormalities.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≤ 45 years. Clinical and laboratory diagnosis of acute myocardial infarction (AMI) based on the Universal Definition of Myocardial Infarction.
- •Voluntary participation with signed informed consent.
排除标准
- •Patients aged > 45 years.
结局指标
主要结局
Incidence and Prevalence of AMI in Patients Aged ≤ 45 Years in Serbia
时间窗: From 01.January 2021.year to 31.December 2026.
The incidence and prevalence of AMI among patients aged ≤ 45 years in Serbia will be reported over the study period, expressed as the number of new and existing cases per 100,000 individuals annually Unit of Measure: "Cases per 100,000 individuals per year."
Demographic Characteristics and Prevalence of Atherosclerotic Risk Factors in Young AMI Patients
时间窗: From 01.January 2021.year to 31.December 2026.
The demographic distribution (e.g., age, gender, socioeconomic status) and prevalence of standard atherosclerotic risk factors (e.g., smoking, diabetes, hypertension, hyperlipidemia) among AMI patients aged ≤ 45 years will be analyzed. Unit of Measure: "Percent of participants with each risk factor."
Angiographic Characteristics in Young AMI Patients
时间窗: From 01.January 2021.year to 31.December 2026.
The presence and extent of obstructive and non-obstructive coronary artery disease, coronary lesions, dissection, and vasospasm will be assessed using angiographic findings. Unit of Measure: "Percent of participants with each angiographic characteristic."
次要结局
- Characteristics of Atherosclerotic Plaque Using OCT or IVUS(From 01.January 2021.year to 31.December 2026.)
- Prevalence of SCAD in Young AMI Patients(From 01.January 2021.year to 31.December 2026.)
- Prevalence of Comorbidities in Young AMI Patients(From 01.January 2021.year to 31.December 2026.)
- Prevalence of Inherited or Acquired Thrombophilia in MINOCA Patients(From 01.January 2021.year to 31.December 2026.)
- Prevalence of Familial Hypercholesterolemia in Young AMI Patients(From 01.January 2021.year to 31.December 2026.)
- Mean Homocysteine Levels in Young AMI Patients(From 01.January 2021.year to 31.December 2026.)
- Treatment Modalities and Interventions in Young AMI Patients(From 01.January 2021.year to 31.December 2026.)
- Number of Participants Experiencing MACE During Hospitalization, at 1 Month, and 1 Year Post-AMI(From 01.January 2021.year to 31.December 2026.)