The Characteristics and Clinical Outcomes of Acute Myocardial Infarction
概览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Xinjiang Medical University
- 入组人数
- 7,350
- 试验地点
- 1
- 主要终点
- Death
概览
简要总结
This study aims to establish a registry and surveillance system for acute myocardial infarction (AMI) patients in Xinjiang, focusing on collecting comprehensive information including basic patient demographics, patient characteristics, diagnostic methods, treatment programs, and hospitalization outcomes such as mortality, treatment complications, hospitalization costs, and follow-up events (death, major adverse cardiac events). The goal is to identify and propose effective prevention strategies to reduce the incidence of AMI, optimize the management and outcomes of AMI patients by implementing guideline recommendations in clinical practice, and conduct analyses to develop effective treatment strategies and predictive models for clinical outcomes. This focus on Xinjiang aims to provide a comprehensive understanding of AMI within this specific geographic and demographic context, ultimately contributing to improved prevention, treatment, and management of AMI patients.
详细描述
The objective of this study is to establish a comprehensive registry and surveillance system for acute myocardial infarction (AMI) patients in Xinjiang. This platform is designed to support clinical research and translational medicine, aiming to improve the quality of AMI patient care through the integration of guideline recommendations into clinical practice. By collecting detailed information on patient demographics, characteristics, diagnostic methods, treatment programs, and outcomes, including mortality, complications, hospitalization costs, and follow-up events such as death and major adverse cardiac events, this study seeks to lay the foundation for future quality improvement initiatives and research. The ultimate goal is to translate research findings into improved care practices for AMI patients, thereby reducing morbidity and mortality associated with the condition. This endeavor will bridge the gap between clinical research and practical healthcare delivery, ensuring that advancements in the treatment and management of AMI directly benefit patients in Xinjiang, contributing to substantial improvements in healthcare outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute myocardial infarction patients in hospitalized of the First Affiliated Hospital of Xinjiang Medical University (include diagnosed acute ST-elevation or non ST-elevation myocardial infarction).Diagnosis criteria must meet Universal Definition for AMI (2012).
排除标准
- •Combined with severe valvular heart disease;
- •Combined with severe congenital heart disease;
- •Combined hyperthyroidism, anemia and other high-powered heart disease;
- •With pulmonary heart disease;
- •With hypertrophic obstructive cardiomyopathy;
- •Severe hypotension (SBP \<90mmHg or DBP \<60mmHg at enrollment);
- •Uncontrolled hypertension (SBP\> 160 mmHg before PCI, and / or DBP\> 100 mmHg);
- •Liver dysfunction (defined as ALT or total bilirubin is greater than the normal upper limit of 3 times);
- •Renal insufficiency (defined as serum creatinine greater than 1.5 times the normal upper limit);
- •High-risk bleeding patients, such as thrombocytopenia, blood diseases and other diseases;
结局指标
主要结局
Death
时间窗: 5 years
All-cause mortality, Cardiac mortality
次要结局
- Major adverse cardiovascular events (MACE)(5 years)
- stroke(5 years)
- Major adverse cardiovascular and cerebrovascular events (MACCE)(5 years)
研究者
Xiang Xie
Xiangxie, MD,Professor, The First Affiliated Hospital Of XinJiang Medicial University
Xinjiang Medical University