Acute Myocardial Infarction in Cancer Patients

Active, not recruiting

• Conditions: Cancer; Acute Myocardial Infarction
• Interventions: Procedure: Revascularization

• Registration Number: NCT06281054
• Lead Sponsor: Samsung Medical Center

Brief Summary

Using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction that can improve long-term prognosis.

Detailed Description

This study will be conducted using Korean National Health Insurance Service database. Patients who were diagnosed with cancer from 2002 to 2021 will be included in the study. Using the selected patients, current study will analyze the incidence and prognosis of acute myocardial infarction in cancer patients and the prognosis according to the treatment method for acute myocardial infarction will be compared. Primary outcome will be all-cause death. Secondary outcomes will be myocardial infarction, revascularization, hospitalization for heart failure, stroke, and clinically relevant bleeding.

Study Timeline

• Study Start: 2002-01-01
• Primary Completion: 2021-12-31
• Study First Submitted: 2024-02-20
• Study First Submitted QC: 2024-02-20
• Study First Posted: 2024-02-28
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-12
• Last Update Posted: 2025-03-14
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 4500000

Inclusion Criteria

• Patients diagnosed with cancer between 2002 and 2021
• Patients who were diagnosed with acute myocardial infarction after cancer diagnosis

Exclusion Criteria

• Patients who died during period of cancer diagnosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Revascularized Group	Revascularization	Cancer patients with diagnosis of acute myocardial infarction that was treated with PCI or CABG

Primary Outcome Measures

Name	Time	Method
All-cause death	2-years after diagnosis of acute myocardial infarction	All-cause death which was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea

Secondary Outcome Measures

Name	Time	Method
Myocardial infarction	2-years after diagnosis of acute myocardial infarction	Myocardial infarction is defined as presence of the diagnostic codes (ICD-10 I21, I22) in the primary position during hospitalization
Revascularization	2-years after diagnosis of acute myocardial infarction	Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
Stroke	2-years after diagnosis of acute myocardial infarction	Stroke is defined as ischemic stroke (ICD-10 I63, I64) or intracranial hemorrhage (ICD-10 I60-62), combined with the codes of diagnostic brain imaging.
Clinically relevant bleeding	2-years after diagnosis of acute myocardial infarction	Bleeding requiring hospitalization or transfusion
Hospitalization for heart failure	2-years after diagnosis of acute myocardial infarction	Heart failure events requiring hospitalization defined as presence of the diagnostic codes (I110, I130, I132, I255, I420, I425-I429, I43, I50, I971) in the primary position during hospitalization

Trial Locations

Locations (1)

Chonnam National University Hospital, Chonnam National University Medical School; 🇰🇷 Gwangju, Korea, Republic of