The Differences Between the Effects of Total Intravenous Anesthesia (TIVA) and Balanced Anesthesia on NK Cell and Cytokine Response in Colorectal Cancer Patients Undergoing Cytoreductive Surgery and HIPEC(Hyperthermic Intraperitoneal Chemotherapy)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Postoperative immune function (NK cell count)
研究概览
简要总结
Anesthetic method was reported to have an impact on postoperative long-term outcome in cancer patients. In this study, we will investigate the effect of different anesthetic methods on NK cell activity, cytokine response and postoperative outcome in colorectal cancer patients undergoing CRS and HIPEC. We will compare propofol-based total intravenous anesthesia (TIVA) with balanced anesthesia to determine the effect of propofol, inhalation agent, and opioid on tumor genesis, recurrence, NK cell activity, cytokine response, and postoperative outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colorectal cancer patients undergoing elective cytoreductive surgery and HIPEC (20-70 yrs old)
- •American Society of Anesthesiologists physical status I, II, III
排除标准
- •Patients under 20 years old.
- •Patients with long-term steroid therapy or immunosuppressive therapy.
- •Patients with long-term NSAIDs therapy.
- •Patients who cannot communicate with other person or with cognitive disorder.
- •Patients who cannot read the consent form.
研究组 & 干预措施
TIVA group
In TIVA group, anesthesia will be maintained by propofol and remifentanil infusion under target controlled infusion.
Other names: fresofol MCT 1% inj®; Fresenius kabi, Seoul, Korea, Ultian inj®; Hanlim, Seoul, Korea
干预措施: anesthetic method (Drug)
Balanced anesthesia group.
Anesthesia will be maintained by sevoflurane and remifentanil infusion in the balanced anesthesia group.
Other names: Sojourn®, Kyongbo, Seoul, Korea, Ultian inj®; Hanlim, Seoul, Korea,
干预措施: anesthetic method (Drug)
结局指标
主要结局
Postoperative immune function (NK cell count)
时间窗: Postoperative day 1
Postoperative immune function will be measured at baseline, POD#1, and POD#7. Postoperative immune function will be investigated by measuring NK cell count.
次要结局
未报告次要终点
研究者
Dong Woo Han
Professor
Gangnam Severance Hospital