Comparison study between perioperative lidocaine and dexmedetomidine infusion for postoperative pain in laparoscopic cholecystectomy patients

Phase 1/2

Completed

• Conditions: Calculus of gallbladder without cholecystitis,

• Registration Number: CTRI/2024/04/064953
• Lead Sponsor: Eras Lucknow Medical College and Hospital

Brief Summary

The Efficacy of Intravenous Lidocaine or Intravenous Dexmedetomidine for post operative pain relief following laparoscopic cystectomy would be determined by this study.

Dexmedetomidine offers significant advantagesover lidocaine in terms of postoperative pain control and reduced analgesicrequirements

Post-operativesedation scores and recovery profile were generally comparable between the twogroups. On the basis of these findings, it could be inferred that perioperativeinfusion of both lidocaine as well as dexmedetomidine was effective in delayingthe post-operative rescue analgesic need with almost similar recovery profile.However, of the two dexmedetomidine had a slight edge over lidocaine both interms of analgesic effect as well as recovery profile.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-05-10
• Study Completion: 2024-07-15
• Study Start: 2024-10-04

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• Patients undergoing Laparoscopic Cholecystectomy under General Anesthesia.
• Age between 18 – 60 years ASA Grade I and II.

Exclusion Criteria

• BMI >30kg/m2.
• Pregnant and Lactating mothers Patients having sinus bradycardia or heart blocks, Patients On steroids.
• History of Allergy to study drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Efficacy of Intravenous Lidocaine or Intravenous Dexmedetomidine for post operative pain relief following laparoscopic cystectomy would be determined by this study	Surgery of max 1hr15mins and followed up for 12hours postoperative period.

Secondary Outcome Measures

Name	Time	Method
The Efficacy of Intravenous Lidocaine or Intravenous Dexmedetomidine for Recovery profile & time to first rescue analgesic following laparoscopic cystectomy would be determined by this study	Surgery of max 1hr15mins & followed up for 12hours postoperative period

Trial Locations

Locations (1)

Eras Lucknow Medical College and Hospital; 🇮🇳 Lucknow, UTTAR PRADESH, India

Eras Lucknow Medical College and Hospital

🇮🇳Lucknow, UTTAR PRADESH, India

Dr Shirin Parveen

Principal investigator

7388732089

shirin_grmc@yahoo.com