NCT01862588Unknown不适用
Clinical Study of Renal Resistive Index and Hemodynamic Parameters Changes Caused by Fluid Resuscitation to Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Zhongda Hospital1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2013年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 7 days AKI occurrence
研究概览
简要总结
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or septic shock patients, to determine whether the changes of resistive index or hemodynamic parameters, especially the cardiac output can be a better parameter to predict AKI
详细描述
- Purpose: To examine whether the resuscitation-induced changes of renal resistive index or hemodynamic parameters has the superiority as a valid tool to evaluate the renal perfusion improvement and whether the changes can better predict AKI occurrence in severe sepsis or septic shock patients.
- Methods: Measure the renal resistive index and take record of hemodynamic parameters (use a PiCCO monitoring to measure cardiac output if the patient's next to kin agree to undertake such a catheter ) before and after successful resuscitation for severe sepsis or septic shock patients, followup to determine the occurrence of AKI and mortality.
- Hypothesis: The changes of resistive index or cardiac output during shock resuscitation may be a better parameter to evaluate renal perfusion and predict AKI, and may have a better value to guide renal protective therapy in septic shock.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥18 years, Sex unlimited
- •Arriving ICU in 6 hours and diagnosed with severe sepsis or septic shock
- •Physician in charge decide that an aggressive fluid resuscitation was in order
排除标准
- •Pregnancy, Age <18 years
- •Ongoing recovery from AKI
- •Known end-stage renal disease or chronic kidney disease(glomerular filtration rate <30mL/min/1.73m2)
- •Known other causes of shock morbidly
- •conditions known to modify RRI, such as renal-artery stenosis, intra-abdominal hypertension(>35cmH2O)
结局指标
主要结局
7 days AKI occurrence
时间窗: 7 days
Follow up to determine the occurrence of AKI in 7 days after inclusion.
次要结局
- eGFR(until 6 hours after enrollment)
研究者
Xiaohua Qiu
physician
Zhongda Hospital
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Resistive Index Measurements After Kidney TransplantationKidney FailureNCT01879124Universitaire Ziekenhuizen KU Leuven346
招募中
不适用
Renal Resistive Index as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in SepsisRenal Resistive IndexSepsisAcute Kidney InjuryNCT06009445Tanta University45
已完成
不适用
Renal Resistive Index in Patients With ShockHypovolemic ShockKidney Failure, AcuteSeptic ShockCardiogenic ShockNCT02558166Amsterdam UMC, location VUmc92
尚未招募
不适用
Role of ultrasound derived kidney index and urine and serum biomarkers in determining the type of kidney injury in patients with liver diseaseCTRI/2020/09/027816Dr Ajay Kumar
尚未招募
不适用
Intraoperative evaluation of Renal Resistive Index with Transesophageal Echocardiography for the assessment of acute renal injury in patients undergoing coronary artery bypass surgeryCTRI/2020/06/025827PGIMER Chandigarh