Renal Resistive Index by Renal Doppler Ultrasound as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis Patients: Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Renal Resistive Index
- Sponsor
- Tanta University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Prediction of AKI development by renal resistance index (RRI)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from admission as a predictor of AKI development
Detailed Description
Acute kidney injury (AKI) is one of the most common problems in critically ill patients in the clinic. AKI can be caused by various factors, such as hypovolemia, shock, major surgery, trauma, and heart failure, of which sepsis is the most common
Investigators
Safinaz Abdelkhalek Aboelfetoh
Resident of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University
Eligibility Criteria
Inclusion Criteria
- •Age over 21 years
- •meet Sepsis 3 criteria (potential source of infection , host response and organ dysfunction) but not in septic shock.
Exclusion Criteria
- •patients during pregnancy.
- •patients with hepatorenal syndrome.
- •Poor abdominal echogenicity eg.(morbid obesity ,increase intra abdominal pressure )
- •Severe acute or chronic renal insufficiency .
- •Dialysis dependency.
- •Renal transplantation.
- •Known renal artery stenosis.
- •Mono-kidney, kidney tumor, anatomic kidney abnormalities.
Outcomes
Primary Outcomes
Prediction of AKI development by renal resistance index (RRI)
Time Frame: 7 days from admission
AKI was defined according to the Kidney Disease Improving Global Outcome (KDIGO) classification using both creatinine and urine output criteria. The KDIGO guidelines define AKI as follows * Increase in serum creatinine by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours, or * Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior seven days, or * Urine volume \<0.5 mL/kg/hour for six hours
Secondary Outcomes
- Length of ICU stay(2 months from admission till discharge)
- The incidence of 28 day mortality(28 days from admission)
- cumulative fluid balance over 7 days(7 days from admission)
- Evaluation of fluid administration(7 days from admission)