Renal Resistive Index by Renal Doppler Ultrasound as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis Patients: Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Prediction of AKI development by renal resistance index (RRI)
研究概览
简要总结
We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from admission as a predictor of AKI development
详细描述
Acute kidney injury (AKI) is one of the most common problems in critically ill patients in the clinic. AKI can be caused by various factors, such as hypovolemia, shock, major surgery, trauma, and heart failure, of which sepsis is the most common
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 21 years
- •meet Sepsis 3 criteria (potential source of infection , host response and organ dysfunction) but not in septic shock.
排除标准
- •patients during pregnancy.
- •patients with hepatorenal syndrome.
- •Poor abdominal echogenicity eg.(morbid obesity ,increase intra abdominal pressure )
- •Severe acute or chronic renal insufficiency .
- •Dialysis dependency.
- •Renal transplantation.
- •Known renal artery stenosis.
- •Mono-kidney, kidney tumor, anatomic kidney abnormalities.
结局指标
主要结局
Prediction of AKI development by renal resistance index (RRI)
时间窗: 7 days from admission
AKI was defined according to the Kidney Disease Improving Global Outcome (KDIGO) classification using both creatinine and urine output criteria. The KDIGO guidelines define AKI as follows * Increase in serum creatinine by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours, or * Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior seven days, or * Urine volume \<0.5 mL/kg/hour for six hours
次要结局
- Length of ICU stay(2 months from admission till discharge)
- The incidence of 28 day mortality(28 days from admission)
- cumulative fluid balance over 7 days(7 days from admission)
- Evaluation of fluid administration(7 days from admission)
研究者
Safinaz Abdelkhalek Aboelfetoh
Resident of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University