Preoperative Renal Resistive Index to Predict Long-term Development of Chronic Kidney Disease in Patients Undergoing Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Long-term renal dysfunction
研究概览
简要总结
Renal resistive index (RRI) is calculated from ultrasonographic Doppler measurements of flow velocities in intraparenchymal renal arteries. Normal values are around 0.60, and 0.70 is considered the upper normal threshold in adults. Both preoperative and postoperative elevation of RRI has shown promise in early detection of AKI after cardiac surgery. Further, elevated RRI before coronary angiography is associated with an increased risk of cardiovascular complications up to 1 year after the procedure. The role of preoperative RRI in predicting long-term renal and cardiovascular complications after elective surgery is however not known. The aim of this study is to assess the role of preoperative RRI to predict the risk of persistent renal dysfunction as well as renal- and cardiovascular complications up to 5 years after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective coronary artery bypass grafting, heart valve surgery, or aortic surgery performed at Karolinska University Hospital between September 2014 and April 2015
- •Preoperative measurement of RRI performed with satisfactory Doppler reading
- •Written informed consent
排除标准
- •Kidney transplant
- •Dialysis-dependent kidney disease
- •Cancelled surgery
- •Missing follow-up data
结局指标
主要结局
Long-term renal dysfunction
时间窗: 5 years after surgery or end of follow-up
Reduced estimated glomerular filtration rate (eGFR) ≥25% from baseline
次要结局
- Major adverse cardiac and cerebrovascular events (MACCE)(30 days, 90 days, 1 year, and 5 years after surgery or end of follow-up)
- Intermediate renal dysfunction(90 days after surgery)
- Major adverse kidney events (MAKE)(30 days, 90 days, 1 year, and 5 years after surgery or end of follow-up)
- Short-term renal dysfunction(30 days after surgery)