Correlation Between Cognitive Functions and MRI in Multiple Sclerosis

• Conditions: Multiple Sclerosis

• Registration Number: NCT00423111
• Lead Sponsor: Sheba Medical Center

Brief Summary

The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.

Detailed Description

Recent literature suggests that multiple sclerosis is accompanied by significant deficits in cognitive performance. The origin of these cognitive deficits is not known, since the severity of cognitive deficits was not found to be correlated with disease parameters such as duration, lesion load or disease intensity as measured on standard scales (e.g. EDSS). The research hypothesis we plan to test is that the individual intensity of cognitive deficits is correlated with degeneration of specific neuronal structures related to cognitive performance, such as the hippocampus and prefrontal cortex.

To test this hypothesis, we plan to perform volumetric measurements of such regions on MRI scans obtained from MS patients during the course of their clinical evaluation, and attempt to correlate those with the results of neuropsychological tests performed by the same subjects around the time of MRI scanning.

Study Timeline

• Study First Submitted: 2007-01-15
• Study First Submitted QC: 2007-01-15
• Study First Posted: 2007-01-17
• Study Start: 2007-02
• Status Verified: 2007-09
• Last Update Submitted: 2007-09-20
• Last Update Posted: 2007-09-21
• Study Completion: 2009-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Clinical diagnosis of Multiple Sclerosis
• Age 18-65

Exclusion Criteria

• Another brain disease
• Stroke
• Brain trauma
• Neurosurgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Sheba Medical Center; 🇮🇱 Ramat Gan, Israel