Validation of a Prognostic Profile of Non Small Cell Lung Cancer in biopsies, PulmoPrint

Withdrawn

• Conditions: lung cancer; Non-small cell lung carcinoma; 10038666

• Registration Number: NL-OMON33429
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

1. Patients with stage I or II of NSCLC who will undergo a resection
2. All histological subtypes of NSCLC
3. signed Informed consent

Exclusion Criteria

1. Prior radiotherapy to target tumor
2. neo adjuvant treatment

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Can the prognosis profile (or other genomic profiles) be performed on biopsy<br /><br>material (feasibility) and is the gene expression in the biopsy sample<br /><br>comparable to the expression in the surgical specimen?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- What percentage of mismatch is due to heterogeneity within the tumor?<br /><br>- What percentage of biopsies has too little (less than 30%) or no cancer cells<br /><br>as assessed by H&E staining?<br /><br>- To what degree correlate the results from biopsy with the results from<br /><br>surgical specimen based on microarray results as well as IHC markers? </p><br>