Effect of colchicine, an anti-inflammatory drug, on the chance of developing atrial fibrillation, a fast irregular heart beat, in open heart surgery patients

Phase 4

Completed

• Conditions: Atrial fibrillation post cardiac surgery; Circulatory System

• Registration Number: ISRCTN15501019
• Lead Sponsor: Jordan Collaborative Cardiology Group

Brief Summary

1. 2016 results in https://www.ncbi.nlm.nih.gov/pubmed/27502857 (added 29/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2015-02-03
• Study Start: 2015-12-31
• Last Update Posted: 17 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

All adult patients undergoing elective cardiac surgery and cared for by participating cardiologists.

Exclusion Criteria

1. Patients with a documented history of AF or supraventricular arrhythmia or, with absence of sinus rhythm on hospital admission
2. Known severe liver disease or current transaminases >1.5 times the upper normal limit
3. Current serum creatinine >2.5 mg/dl
4. Known myopathy or elevated baseline preoperative creatine kinase
5. Known blood dyscrasias
6. Significant gastrointestinal disease
7. Pregnant and lactating women
8. Known hypersensitivity to colchicine
9. Current treatment with colchicine for any indications
10. Emergency surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified