Impact of Impaired barrier function in duodenal mucosa to functional dyspepsia: discovering the pathophysiology and developing new therapeutic strategy
Not Applicable
Recruiting
- Conditions
- functional dyspepsia (FD)
- Registration Number
- JPRN-UMIN000028693
- Lead Sponsor
- Division of Gastroenterology Tohoku University Graduate School of Medicine
- Brief Summary
TEER in duodenal epithelium was decreased more than that in healthy volunteer against weaky acid stimulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Only healthy volunteer 1. medication such as acid suppressive drug, Nsaids, steroids or immune suppressive drug 1 month prior to the study All participants 1. past history of or scheduled abdominal surgery 2. forbidden in endoscopic examination (e.g. coagulation disorder) 3. pregnancy 4. severe healthy status 5. psychological disorder 6. those who are judged inappropriate to entry the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of difference in duodenal barrier function between FD patients and healthy volunteer
- Secondary Outcome Measures
Name Time Method Comparison of the difference in duodenal barrier function among FD with or without non erosive reflux disease (NERD) and healthy volunteer