The effect of a ketogenic diet (KD) - a very low carbohydrate and high-fat diet - without caloric restrictions on endurance capacity in healthy adults.

Not Applicable

• Conditions: Healthy participants

• Registration Number: DRKS00009605
• Lead Sponsor: niversitätsklinikum Freiburg; Klinik für Innere medizin I; Hämatologie, Onkologie und Stammzelltransplantation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-08
• Study Completion: 2016-07-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

•?Age >18 years
•?Body mass index 19-30 kg/m2
•?Weight loss <5% of body weight in the last 6 months
•?Adequate renal function (serum creatinine < 1.5 X UNL [upper normal limit] or creatinine clearance > 50 ml/min)
•?Adequate liver function: bilirubin = 1.5 x upper limit of normal (UNL) range, ALAT and/or ASAT = 2.5 x UNL, Alkaline Phosphatase =5 x UNL
•?Written informed consent

Exclusion Criteria

• Known G6PD (glucose-6-phosphate dehydrogenase) deficiency
• Diabetes mellitus undergoing therapy with insulin or oral agents
• Kidney stones
• Pregnant or lactating women
• Disorders of fatty acid metabolism: carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I or II deficiency, carnitine translocase deficiency, ß-oxidation defects, short-chain acyl dehydrogenase deficiency (SCAD), medium-chain acyl dehydrogenase deficiency (MCAD), long-chain acyl dehydrogenase deficiency (LCAD), medium-chain 3-hydroxyacyl-CoA deficiency, long-chain 3-hydroxyacyl-CoA deficiency, pyruvate carboxylase deficiency, porphyria

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endurance capacity [Maximum rate of oxygen consumption - VO2max (mL/kg*min)] via cycle ergometer (before and after 6 weeks of ketogenic diet)<br>

Secondary Outcome Measures

Name	Time	Method
All secondary endpoints will be measured before and after 6 weeks of ketogenic diet. <br>- Physical strength (Maximum strength of upper leg muscles) via isokinetic test system<br>- Basal metabolic rate (respiratory quotient) via indirect calorimetry<br>- Body composition (Fat and fat-free mass) via whole-Body Air Displacement Plethysmography<br>- Laboratory values (serum): liver function, renal function and fasting lipid profile, ketone bodies, glucose, insulin, IGF-1, CRP<br>- Metabolic parameters (urine): ketone bodies via reagent strips<br>