The effect of a short-term ketogenic diet on cognitive function, sleep, fatigue, heart rate variability and mood.

Not Applicable

Completed

• Conditions: Mental Health - Studies of normal psychology, cognitive function and behaviour; Cognitive function; Sleep; Fatigue; Mood; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12621000105842
• Lead Sponsor: ew Zealand Defence Force

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-02
• Study Completion: 2021-05-31
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

1) aged 18-50 years; 2) non-obese (i.e. body mass index < 30); 3) healthy; 4) consuming a mixed-diet; 5) habitually going to sleep between 2100-0000 h and waking between 0600-0900 h.

Exclusion Criteria

1) habitually consuming a ketogenic diet or exogenous ketones within the previous 2 years; 2) smoker; 3) average caffeinated beverage consumption more than 3 cups per day; 4) have a medical, psychiatric or sleep disorder; 5) habitually sleep less than 7 h or more than 9 h; 6) regularly consume medications or medications acting on the central nervous system; 7) history of drug or alcohol abuse; 8) food allergies or engaging in restrictive dietary patterns; 9) trans-meridian travel or shift-work in the 28 days prior to the study.

Participants will also be required to have an Epworth Sleepiness score less than 10; a global Pittsburgh Sleep Quality Index score equal to or less than 5; normal scores on the 21-item Depression Anxiety Stress scale; and scoring as moderately evening or intermediate chronotype on the Horne-Ostberg Morningness/Eveningness questionnaire.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function using a computerised test battery. [Day 7 and 14 during the dietary adaptation period and at 2 hourly intervals during the extended wakefulness period.];Sleep using actigraphy and written diary. [Daily during the dietary adaptation period. ];Heart rate variability using photoplethysmography via mobile phone application. [Daily during the dietary adaptation phase.]

Secondary Outcome Measures

Name	Time	Method
Mood using a validated subjective questionnaire from the Automated Neuropsychological Assessment Metrics test battery. [Daily during the dietary adaptation phase and at 2 hourly intervals during the extended wakefulness phase.];Sleepiness using a subjective questionnaire (i.e. Stanford Sleepiness Scale). [Daily during the dietary adaptation phase and at 2 hourly intervals during the extended wakefulness phase.];Capillary blood glucose concentration using point-of-care device. [Daily during the dietary adaptation phase and at 2 hourly intervals during the extended wakefulness phase.];Hunger using a study-specific subjective questionnaire. [Daily during the dietary adaptation phase and at 2 hourly intervals during the extended wakefulness phase.];Capillary D-beta-hydroxybutyrate concentration using point-of-care device. [Daily during the dietary adaptation phase and at 2 hourly intervals during the extended wakefulness phase.]