A comparative study of melatonin and gabapentin in reducing preoperative anxiety
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Difference in the change in VAS anxiety score
Study Overview
Brief Summary
Reductionin preoperative anxiety reduces postoperative pain, improves post surgeryrecovery and even leads to early discharge. In addition providing analgesiabefore the start of surgery(Preemptive analgesia) has been also been associatedwith reduced postoperative pain. Patients suffering from trauma have highstress levels making them it even more pertinent to tackle preoperative anxietyand pain. Through this project we intend to find the appropriate premedicationwhich reduces preoperative anxiety and thereby reduces postoperative pain andthus improves patient outcome.
ExpectedOutcome**:** It isexpected that melatonin will be superior to alprazolam and gabapentin inreducing preoperative anxiety as well as postoperative analgesic requirements.
Study Design
- Study Type
- Interventional
- Allocation
- Permuted block randomization, fixed
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •PAtients undergoing routine surgery after trauma ASA I and asa II patients.
Exclusion Criteria
- •a)Patients for emergency surgeries b)Surgeries taking place after 1pm (to account for diurnal variation in cortisol levels) c)Patients having altered mental state, history of psychiatric disorder, history of drug abuse or those on chronic pain medication.
Outcomes
Primary Outcomes
Difference in the change in VAS anxiety score
Time Frame: Difference in the change in VAS anxiety score at 90 minutes after drug administration
Secondary Outcomes
- Change in IL6 and serum cortisol levels(90 minutes post drug administration)