which drug reduces preoperative anxiety

Completed

• Conditions: Injury, poisoning and certain other consequences of external causes,

• Registration Number: CTRI/2023/01/049073
• Lead Sponsor: AIIMS New delhi

Brief Summary

Reductionin preoperative anxiety reduces postoperative pain, improves post surgeryrecovery and even leads to early discharge. In addition providing analgesiabefore the start of surgery(Preemptive analgesia) has been also been associatedwith reduced postoperative pain. Patients suffering from trauma have highstress levels making them it even more pertinent to tackle preoperative anxietyand pain. Through this project we intend to find the appropriate premedicationwhich reduces preoperative anxiety and thereby reduces postoperative pain andthus improves patient outcome.

ExpectedOutcome**:** It isexpected that melatonin will be superior to alprazolam and gabapentin inreducing preoperative anxiety as well as postoperative analgesic requirements.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-18
• Study Completion: 2023-12-20
• Last Update Posted: 2024-05-03

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

PAtients undergoing routine surgery after trauma ASA I and asa II patients.

Exclusion Criteria

a)Patients for emergency surgeries b)Surgeries taking place after 1pm (to account for diurnal variation in cortisol levels) c)Patients having altered mental state, history of psychiatric disorder, history of drug abuse or those on chronic pain medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in the change in VAS anxiety score	Difference in the change in VAS anxiety score at 90 minutes after drug administration

Secondary Outcome Measures

Name	Time	Method
Change in IL6 and serum cortisol levels	90 minutes post drug administration

Trial Locations

Locations (1)

AIIMS, new delhi; 🇮🇳 South, DELHI, India

AIIMS, new delhi

🇮🇳South, DELHI, India

Kelika Prakash

Principal investigator

9540947117

kelika.prakash@gmail.com