Epidemiologic Study of Hepatocellular Carcinoma in the US

Completed

• Conditions: Hepatocellular Carcinoma

• Registration Number: NCT02358070
• Lead Sponsor: Stanford University

Brief Summary

The purpose of this study is:

* to investigate the risk factors of HCC among Americans with focus on lifestyle factors and energy balance.

* to identify single nucleotide polymorphisms (SNPs) and haplotypes that are associated with HCC risk through a genome-wide search.

* to assess if genetic susceptibility differs by hepatitis virus infection or lifestyle factors, and to explore if there are interplays or effect modifications between genetic factors and viral infection or lifestyle factors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-01-29
• Study First Submitted QC: 2015-02-05
• Study First Posted: 2015-02-06
• Study Start: 2015-04
• Primary Completion: 2016-09-01
• Study Completion: 2016-09-01
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-20
• Last Update Posted: 2020-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lifetime physical activity	20 years	Lifetime physical activity will be measured by collecting data on major types of physical activity separately and by determining frequency, intensity, and duration of each activity using a combined modification of Friedenreich's lifetime physical activity questionnaire and Kriska's past year physical activity questionnaires.
Energy intake	20 years	A modified Food Frequency questionnaire based on one developed by Dr. Alan Kristal from the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle will capture energy intake by differentiating low-fat food options from higher-fat counterparts.
Lifestyle factors	20 years	Structured questionnaires will be used to elicit information on demographic, anthropometric, and socioeconomic factors, long-term use of medications, medical history, and family history of cancer, cigarette smoking and alcohol consumption, physical activity, and dietary habits. Additional information unrelated to liver cancer will be included in the questionnaire to help assess possible recall bias.

Trial Locations

Locations (1)

Stanford Liver Transplant Clinic; 🇺🇸 Stanford, California, United States