Can Pre-operative High Intensity Interval Exercise Improve Surgical Outcomes After Major Abdominal Surgery?

Not Applicable

Withdrawn

• Conditions: Surgical complications following major upper gastrointestinal surgery.; Oespohageal Cancer; Surgery - Other surgery; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12619001094167
• Lead Sponsor: Hunter New England Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-09
• Last Update Posted: 5 September 2022

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Aged 18 years and over
- Written informed consent
- Operative procedure planned at least 4 weeks from randomisation date
Patient must be assessed as fit for surgery by the treating Surgeon based on past medical history and CPET testing.
- Patient must be undergoing a major upper gastrointestinal surgical procedure with neoadjuvant therapy including the following:
* Oesophagectomy
* Total/ Subtotal Gastrectomy
* Pancreaticoduodenectomy
* Major Liver Resection( >2 segments)

Exclusion Criteria

Unresectable/ metastatic disease at any point within the study
- Progressive disease during neoadjuvant chemotherapy
- Known Class III/IV heart failure or moderate to severe pulmonary hypertension
- Poorly controlled cardiac arrhythmia/ excluded by an anaesthetist or a cardiologist
- Uncontrolled hypertension >180/100
- Angina
- Claudication
- Vascular aneurysm
- Severe COPD with FEV1<50% predicted
- For safety reasons, the study cannot enrol people who don’t speak basic English as in a maximal intensity exercise program we cannot provide a safe environment without a trained, NSW Health registered translator for every exercise session.
- Clinical decision by treating Surgeon that operative procedure will be scheduled less than 4 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified