utrient sensing in response to starvation in obese and lean individuals
- Conditions
- Obesity10000546
- Registration Number
- NL-OMON34778
- Lead Sponsor
- niversitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Healthy males and females
Age 19-60 yrs
Obese subjects: BMI >30 kg/m2
Lean controls: BMI 19-25 kg/m2
Stable weight for the last 3 months
Caucasian
FPG < 6 mmol/L
Hb > 7.5 mmol/l
Negative family history of DM2 (first degree family members)
Use of medication known to affect glucose and/or lipid metabolism
History of genetic or psychiatric disease that affects the brain
Significant chronic disease
Renal or hepatic disease
Pregnancy
Smoking (current)
Alcohol consumption of more than 28 units per week at present or in the past
Recent blood donation (within the last 3 months)
Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Contra-indication to MRI scanning
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Activity of energy sensing machinery, measured from muscle biopsies<br /><br>HPA axis activity, measured by blood sampling<br /><br>HPT axis activity, measured by blood sampling<br /><br>Resting-state networks in the brain, measured by FMRI<br /><br>MRI volumetric measurements of amygdale and hippocampus<br /><br>Fat and glucose oxidation rates measured by indirect calorimetry</p><br>
- Secondary Outcome Measures
Name Time Method <p>NA</p><br>