utrient sensing in response to starvation in obese and lean individuals.
Recruiting
- Conditions
- obesity
- Registration Number
- NL-OMON29226
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy males and females;
2. Age 19-60 yrs;
Exclusion Criteria
1. Use of medication known to affect glucose metabolism (for example prednisone) or lipid metabolism;
2. History of genetic or psychiatric disease (e.g. fragile X syndrome, major depression) that affects the brain;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome are biochemical parameters (eg AMPK, Sirtuins) measured in muscle biopsies.<br /><br>These will be obtained before and after 60 hours of starvation and for the obese group after the weight loss intervention as well.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are: Antropometrics, fMRI, heart rate variability, biometric impedance analysis, blood pressure and pulse, indirect calorimetry and blood samples.<br /><br>All will be obtained before and after 60 hours of starvation and for the obese group after the weight loss intervention as well.