The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis
- Conditions
- SepsisSeptic Shock
- Registration Number
- NCT04644926
- Lead Sponsor
- Lithuanian University of Health Sciences
- Brief Summary
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
- Detailed Description
This prospective open-label trial is performed in mixed ICU in a tertiary teaching hospital. Investigators include patients with sepsis or septic shock within the first 24 h after ICU admission. Remote ischemic conditioning (RIC) procedure comprise three repetitions of brachial cuff inflation to 200 mmHg for five minutes following deflation to 0 mmHg for another five minutes. The procedure overall took 30 minutes. RIC is performed at inclusion and repeated 12 h and 24 h later. Sublingual microcirculatory measurements are obtained before and after each RIC procedure, using incidence dark field (IDF) device.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
- Patients with sepsis or septic shock within the first 24 h after ICU admission.
- age < 18 years,
- pregnancy,
- advanced malignancy,
- peripheral artery disease affecting both arms,
- oral mucosal inflammation or injury or technical difficulties in obtaining sublingual images.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Microvascular flow index (MFI) and Proportion of perfused small vessels (PPV) 30 minutes The differences in MFI and PPV between pre- and post-RIC performance.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital of Lithuanian university of health sciences
🇱🇹Kaunas, Lithuania
Hospital of Lithuanian university of health sciences🇱🇹Kaunas, Lithuania