A rinse or a drink? An exploration of blackcurrant juice-mediated MAO-B inhibitio

Not Applicable

• Conditions: Cognitive stress & support; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12623000247673
• Lead Sponsor: Dr Jocelyn Eason

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-08
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Healthy individual (male or female) 18 – 45 years, BMI between 18-30kg/m2 who are able to provide written consent to participate when selected for this study.

Exclusion Criteria

Participants will be excluded if they are unwilling or unable to provide written consent or comply with the study procedures. Participants will also be excluded if they have known hypersensitivity or intolerance to blackcurrants or food products derived from these ingredients. In addition, participants will be excluded if they are pregnant, planning to get pregnant in the immediate future or have any of the following conditions: (i) blood borne diseases (e.g. hepatitis), (ii) recent bacterial/viral illness or taken antibiotics, (iii) are taking medication that affects the properties of blood (e.g. blood clotting) or immune function, (iv) history of gastrointestinal disorders, (v) chronic/psychiatric conditions, (vi)being on controlled diet and have had significant weight loss in previous six month, (vii) excessive alcohol intake (>21 drinks a week), (viii) aversion to blood sampling, (ix) are a current smoker/vaper,(x). unable to complete the cognitive tasks.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in Platelet monoamine oxidase-B activity (MAO-B) using a commercial assay kit.[MAO-B enzyme activity will be measured in platelet samples isolated from whole blood and will be analysed using a commercial assay kit. At each visit, seven blood samples will be collected. Samples collected will include baseline upon arrival at the laboratory and 2, 5, 10, 20, 60 min post-intervention and at the completion of the cognitive test.]