A study investigating whether sleep can be measured accurately at home in people with early Alzheimer’s disease

Not Applicable

• Conditions: Dementias and neurodegeneration, Alzheimer's disease; Nervous System Diseases

• Registration Number: ISRCTN17814224
• Lead Sponsor: niversity of Bristol

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-22
• Last Update Posted: 3 April 2023
• Study Completion: 2025-04-14

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

For Sub-Study 1:
1. Age > 50 years
2. All participants must express that they are willing to take part in this study and adhere to the study procedures
3. Full capacity to consent to involvement
4. Clinical diagnosis of MCI due to AD or mild AD according to standardised criteria

For Sub-Study 2:
1. All participants undergoing CSF testing clinically including CSF biomarkers of AD.
2. All participants must express that they are willing to take part in this study and adhere to the study procedures.
3. Full capacity to consent to involvement

Exclusion Criteria

For Sub-Study 1
1. Severe medical or psychiatric co-morbidity, which, in the opinion of the investigator, may substantially impact on sleep.
2. Clinically significant sleep disorder as defined by ICD-10 or equivalent pre-dating and / or not related to AD pathology.
3. Diagnosis of dementia other than AD.
4. Montreal Cognitive Assessment (MoCA) < 11/30

For Sub-Study 2
1. Severe medical or psychiatric co-morbidity, which, in the opinion of the investigator, may substantially impact on the ability to tolerate withdrawal of an extra 10ml of blood.

Study & Design

• Study Type: Observational
• Study Design: Not specified