Comparing the Diagnostic Role of 18F-FDG PET/MRI and of 18F-FDG PET/CT Among Patients With Gastric Cancer：A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastric Cancer Stage
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 100
- Primary Endpoint
- The results of the PET/MRI and PET/CT examination
- Last Updated
- 9 years ago
Overview
Brief Summary
The results of PET/MRI and PET/CT in each recruited gastric cancer patients will be compared.
Detailed Description
A prospective comparison of PET/MRI and PET/CT for gastric cancer will be performed,to evaluate the value of PET/MRI in predicting the preoperative staging and resectability of gastric cancer and investigate the role of PET/MRI in gastric cancer diagnosis.The evaluation parameters are the diagnostic accuracy of gastric cancer staging( including the overall accuracy, sensitivity, and specificity) and the receiver operating characteristic (ROC).
Investigators
Lin Chen
Director
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Histological diagnosis of gastric cancer
- •No previous treatment history for gastric cancer
- •Without complications of obstruction,bleeding and so on
- •Without severe diabetes,the levels of blood glucose \<6.2 mmol/L .
- •No cardiac pacemarker,never stimulator or other metal substitute materials in vivo.
Exclusion Criteria
- •With other neoplastic disease.
- •Suffering acute inflammatory disease
- •History of chemo-radiotherapy
- •Suffering prostate hyperplasia,glaucoma
Outcomes
Primary Outcomes
The results of the PET/MRI and PET/CT examination
Time Frame: 3 days
Two experienced radiologists independently assess the TNM staging of gastric cancer using preoperative PET/MRI and PET/CT images
Secondary Outcomes
- Apparent Diffusion Coefficient(ADC)(3 days)
- The expression level of Receptor tyrosine-protein kinase erbB-2(HER2)(5 days)
- Histopathological diagnosis(5 days)
- Results of CT/Endoscopic ultrasound(EUS) image(3 days)
- Follow-up data(at lest 6 months)
- Numerical values of Standard uptake value(SUV)(3 days)
- The expression level of Receptors for vascular endothelial growth factor(VEGFR)(5 days)