Comparing the Diagnostic Role of 18F-FDG PET/MRI and of 18F-FDG PET/CT Among Patients With Gastric Cancer：A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 主要终点
- The results of the PET/MRI and PET/CT examination
研究概览
简要总结
The results of PET/MRI and PET/CT in each recruited gastric cancer patients will be compared.
详细描述
A prospective comparison of PET/MRI and PET/CT for gastric cancer will be performed,to evaluate the value of PET/MRI in predicting the preoperative staging and resectability of gastric cancer and investigate the role of PET/MRI in gastric cancer diagnosis.The evaluation parameters are the diagnostic accuracy of gastric cancer staging( including the overall accuracy, sensitivity, and specificity) and the receiver operating characteristic (ROC).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological diagnosis of gastric cancer
- •No previous treatment history for gastric cancer
- •Without complications of obstruction,bleeding and so on
- •Without severe diabetes,the levels of blood glucose <6.2 mmol/L .
- •No cardiac pacemarker,never stimulator or other metal substitute materials in vivo.
排除标准
- •With other neoplastic disease.
- •Suffering acute inflammatory disease
- •History of chemo-radiotherapy
- •Suffering prostate hyperplasia,glaucoma
结局指标
主要结局
The results of the PET/MRI and PET/CT examination
时间窗: 3 days
Two experienced radiologists independently assess the TNM staging of gastric cancer using preoperative PET/MRI and PET/CT images
次要结局
- Apparent Diffusion Coefficient(ADC)(3 days)
- The expression level of Receptor tyrosine-protein kinase erbB-2(HER2)(5 days)
- Histopathological diagnosis(5 days)
- Results of CT/Endoscopic ultrasound(EUS) image(3 days)
- Follow-up data(at lest 6 months)
- Numerical values of Standard uptake value(SUV)(3 days)
- The expression level of Receptors for vascular endothelial growth factor(VEGFR)(5 days)
研究者
Lin Chen
Director
Chinese PLA General Hospital