Quality of Life After Radiotherapy & Steroids. A Phase III Multi-Centre Randomised Controlled Trial to Assess Whether Optimal Supportive Care Alone (Including Dexamathasone) is As Effective (in terms of Patient Assessed Quality Adjusted Life Years) as Optimal Supportive Care (Including Dexamethasone ) Plus Whole Brain Radiotherapy in the Treatment of Patients With Inoperable Brain Metastases From Non-Small Cell Lung Cancer

Tanya Holt0 个研究点目标入组 1,000 人开始时间: 2007年5月17日最近更新: 2020年1月13日

适应症

试验速览

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•Histologically or cytologically proven primary Non Small Cell Lung Cancer- Computed Tomography(CT)/Magnetic Resonance Imaging (MRI) confirming brain metastases - Inoperable brain metastases as assessed by a lung cancer Multi-Disciplinary Team (MDT) or patients for whom surgery is deemed inappropriate- Clinician and patient uncertain of the role of WBRT- Patient able and willing to respond to questions in a weekly telephone assessment- Patient able and willing to give informed consent- Baseline Patient Assessment Form completed.

•Clinician and / or patient certain that WBRT will be of benefit- Clinician and / or patient certain that WBRT will not be of benefit - Previous or current illness, which has not been brought under control and/or is likely to interfere with protocol treatment or comparisons- Epidermal Growth Factor Receptor (EGFR) inhibitors within one week prior to randomisation- Chemotherapy (last cycle) within one month prior to randomisation- Previous radiotherapy to the brain- Surgery for brain metastases within one month prior to randomisation

发起方

Tanya Holt