The impact of taste of metamizole on the pain perception of healthy volunteers

Not Applicable

Recruiting

• Conditions: Healthy volunteers; R52.0; Acute pain

• Registration Number: DRKS00022805
• Lead Sponsor: niversitätsklinikum EssenKlinik für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 165

Inclusion Criteria

Voluntary consent, healthy

Exclusion Criteria

Any acute and chronic illness/infection, use of medication in the last 7 days, alcohol and drug abuse, alcohol use 24 hours prior to participation, allergy to one of the substances used, participation in a clinical trial in the last 6 months, general anaesthesia in the last 6 months, knowledge of German in writing and language. For women: pregnancy, breast-feeding.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the change in the area under the pain curve (AUPC, =AUC, in %) during the cold pressor test from baseline to test (about 30 minutes after taking the study medication) as a measure of pain intensity in a group comparison.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoint is the change in pain tolerance (time to stop cold pressor test in seconds) as a surrogate marker of pain intensity from baseline to test in group comparison. Side effects and psychometric and vital parameters are collected exploratively.