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Metamizol for the Treatment of Neoplastic Chronic Pain

Registration Number
NCT02181920
Lead Sponsor
Boehringer Ingelheim
Brief Summary

Study to evaluate the efficacy of metamizole in reducing morphine requirements in patients with moderate to severe chronic cancer pain in comparison to administration of placebo or diclofenac.

Detailed Description

Not available

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
6
Inclusion Criteria
  • Hospitalized patients with neoplastic chronic pain requiring morphine treatment
Exclusion Criteria
  • Karnofsky index less than 30%

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
Placebo - MetamizoleMetamizoleplacebo followed by metamizole
Metamizole - DiclofenacDiclofenacmetamizole followed by diclofenac
Diclofenac - MetamizoleMetamizolediclofenac followed by metamizole
Diclofenac - MetamizoleDiclofenac placebodiclofenac followed by metamizole
Metamizole - PlaceboDiclofenac placebometamizole followed by placebo
Metamizole - PlaceboMetamizole placebometamizole followed by placebo
Placebo - MetamizoleMetamizole placeboplacebo followed by metamizole
Metamizole - DiclofenacMetamizolemetamizole followed by diclofenac
Diclofenac - MetamizoleMetamizole placebodiclofenac followed by metamizole
Metamizole - DiclofenacDiclofenac placebometamizole followed by diclofenac
Metamizole - DiclofenacMetamizole placebometamizole followed by diclofenac
Placebo - MetamizoleDiclofenac placeboplacebo followed by metamizole
Diclofenac - MetamizoleDiclofenacdiclofenac followed by metamizole
Metamizole - PlaceboMetamizolemetamizole followed by placebo
Primary Outcome Measures
NameTimeMethod
Change in morphine requirementBaseline, 9 days
Secondary Outcome Measures
NameTimeMethod
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