Improvement of Diagnostic mEthods for ALlergy assessment. Cashew allergy in children as a showcase (IDEAL study)

Completed

• Conditions: food allergy; IgE mediated allergy; 10016950

• Registration Number: NL-OMON41456
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients with a possible cashew nut allergy and a positive skin test (Histamine Equivalent Prick HEP > 0.2) or a positive CAP FEIA (> 0.35) with cashew nut extract.
Age 2-17 (incl.) years.
Written consent of parents (guardian) and -if 12 years and above- the patient.

Exclusion Criteria

Severe or uncontrolled asthma and/or recent (< 1 year) intensive care unit admissions.
Severe eczema defined as TIS (Three Item Severity) eczema score ( > 6).
Immunological diseases, cardiovascular diseases or malignancy.
Severe psychosocial problems.
Not able to stop anti-histamine medication for a short period.
Use of beta-blockers.
The patient is allergic to one or more of the ingredients of the food matrix, unless a suitable substitute for the ingredient in question can be found.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Results of Mediator Release Assays in comparison with regular tests.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Adverse events, prevalence of allergy to cashew nuts.<br /><br>Genetic research.</p><br>