Improvement of Foodallergy Diagnostic in Gastrointestinal Tract
Not Applicable
Completed
- Conditions
- Food Allergy
- Interventions
- Diagnostic Test: Cytobrush
- Registration Number
- NCT03151252
- Lead Sponsor
- University of Erlangen-Nürnberg Medical School
- Brief Summary
Currently, diagnostic possibilities for the detection of food allergy in the gastrointestinal tract are scarce. The endoscopic segmental Lavage is the method of choice, but it´s controversial.
Additional to the endoscopic segmental lavage fluid a cytobrush is used for collecting the mucosa cells and biopsies are taken. Comparative to the Lavage specific IgE antibodies, Tumor necrosis factor- alpha, Eosinophilic cation protein and mastcell tryptase were measured.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- all patients with suspicion of food intolerance and confirmed food allergy
Exclusion Criteria
- pregnant and patients under allergy medication (antihistaminic, cortison)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Food allergy Cytobrush Patients with confirmed foodspecific- IgE antibodies in blood gastointestinal symptoms without foodallergy in blood Cytobrush Patients without foodspecific- IgE antibodies in blood, but with gastrointestinal symptoms healthy controls Cytobrush participants without foodspecific- IgE antibodies in blood and other gastrointestinal symptoms
- Primary Outcome Measures
Name Time Method detection of specific IgE Antibodies in colon 1 hour
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg
🇩🇪Erlangen, Germany