The Relationship Between Maximal Oxygen Consumption and Inspiratory Muscle Activation Pattern Under Loaded Inspiratory Muscle Tests in Healthy Adults

Completed

• Conditions: Healthy
• Interventions: Other: Loaded inspiratory muscle test and cardiopulmonary exercise test

• Registration Number: NCT04463732
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Maximal oxygen consumption, VO2max, is the gold standard to evaluate human aerobic fitness, which stands for the maximal capacity of cardiorespiratory system and musculoskeletal system to transport and utilize oxygen. Previous study showed that there is significant correlation between maximal oxygen consumption from cardiopulmonary exercise test and strength and endurance of lower extremities. In people with sedentary lifestyle, they often limited by the lower limb muscle performance during cardiopulmonary exercise test. Their breathing patterns are more irregular than athletes during cardiopulmonary exercise test. However, there is no study comparing the activation pattern of respiratory muscles between these two groups. Whether the breathing pattern in people with lower exercise capacity is less efficient under exertional activities still unknown. The purpose of this study is to investigate the relationship between maximal oxygen consumption and inspiratory muscle activation pattern in healthy adults.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-06
• Study First Submitted: 2020-06-29
• Study Start: 2020-07-01
• Study First Submitted QC: 2020-07-03
• Study First Posted: 2020-07-09
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Last Update Submitted: 2021-03-16
• Last Update Posted: 2021-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy adults (age > 20 years old)
• Be able to cooperate with the measurements of this study

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Exclusion Criteria

• any clinical diagnosis that will influence the measurement, including any history of neuromyopathy
• angina, acute myocardial infarction in the previous one month
• pregnancy
• history of syncope during exercise
• any musculoskeletal system disorder that unable to perform cardiopulmonary exercise test

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy group	Loaded inspiratory muscle test and cardiopulmonary exercise test	Subjects are above 20 years old. Their condition is healthy with no history of inspiratory disease. They can cooperate with the measurements of this study.

Primary Outcome Measures

Name	Time	Method
Maximal exercise capacity	during the cardiopulmonary exercise test; it would take about 12 to 15 minutes	Maximal oxygen consumption
Diaphragm and Sternocleidomastoid muscle activation	during the loaded inspiratory muscle test condition; it would take about 3 minutes	Root mean square values

Trial Locations

Locations (1)

School and Graduate Institute of Physical Therapy of National Taiwan University; 🇨🇳 Taipei, Zhongzheng Dist, Taiwan