Assessment of GARP Expression and Inflammatory Cytokines in Acute and Chronic Coronary Syndrome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Platelet GARP expression
Study Overview
Brief Summary
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Older than 18 years
- •Able to give informed consent
- •Undergoing coronary angiography.
Exclusion Criteria
- •Patients younger than 18 years
- •Unable to give consent
- •Pregnancy
Arms & Interventions
Acute coronary syndrome
This arm includes patients undergoing coronary angiography with a final diagnostic of acute coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
Intervention: Arterial blood sample (Biological)
Chronic coronary syndrome
This arm includes patients undergoing coronary angiography with a final diagnostic of chronic coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
Intervention: Arterial blood sample (Biological)
Control
This arm includes patients undergoing coronary angiography with a final diagnostic of non significant coronary disease. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
Intervention: Arterial blood sample (Biological)
Outcomes
Primary Outcomes
Platelet GARP expression
Time Frame: Throughout the entire study, approximately during 2 years
The platelet GARP expression profile will be assessed and compared between arms using flow cytometry.
Secondary Outcomes
- Inflammatory profile(Throughout the entire study, approximately during 2 years)