Assessment of GARP Expression and Inflammatory Cytokines in Acute and Chronic Coronary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Platelet GARP expression
研究概览
简要总结
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years
- •Able to give informed consent
- •Undergoing coronary angiography.
排除标准
- •Patients younger than 18 years
- •Unable to give consent
- •Pregnancy
研究组 & 干预措施
Acute coronary syndrome
This arm includes patients undergoing coronary angiography with a final diagnostic of acute coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
干预措施: Arterial blood sample (Biological)
Chronic coronary syndrome
This arm includes patients undergoing coronary angiography with a final diagnostic of chronic coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
干预措施: Arterial blood sample (Biological)
Control
This arm includes patients undergoing coronary angiography with a final diagnostic of non significant coronary disease. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.
干预措施: Arterial blood sample (Biological)
结局指标
主要结局
Platelet GARP expression
时间窗: Throughout the entire study, approximately during 2 years
The platelet GARP expression profile will be assessed and compared between arms using flow cytometry.
次要结局
- Inflammatory profile(Throughout the entire study, approximately during 2 years)