ANTICS: Antibiotic implant in cardiac surgery

Not Applicable

Completed

• Conditions: Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Injury, Occupational Diseases, Poisoning; Sternal wound infection

• Registration Number: ISRCTN57443262
• Lead Sponsor: Plymouth Hospitals NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02-17
• Last Update Posted: 5 June 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Aged 18 years or older, either sex
2. Undergoing cardiac surgery through the sternum (sternotomy)
3. Provided informed consent to participate

Exclusion Criteria

1. Patients admitted for emergency surgery
2. Pregnant or lactating females
3. Patients with a known hypersensitivity to collagen and/or gentamicin and other aminoglycoside antibiotics
4. Patients with a history of autoimmune diseases in which gentamicin is contraindicated (e.g., Parkinson's disease or myasthenia gravis)
5. Serum creatinine more than 200 µmol/l within 2 weeks pre-operatively
6. Chronic renal failure on dialysis
7. Participating in another clinical research study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ASEPSIS score, measured at day 2, day 4 and week 8 following surgery

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration