A randomised, control, assessor blinded, dose escalating study to compare high dose rocuronium and suxamethonium for use in rapid sequence inductionof anaesthesia - Rocuronium or suxamethonium for rapid sequence inductio
Phase 1
- Conditions
- Patients undergoing Anaesthesia
- Registration Number
- EUCTR2004-002715-92-GB
- Lead Sponsor
- Royal Group Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
ASA class I-III
aged 18-65
scheduled to undergo elective surgery
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Pregnancy
Taking medication known to interact with neuromuscular blocking drugs
Known or suspected anaphylaxis to any of the study medications
Suspected difficult intubation
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To find the dose of rocuronium that provides conditions equal to those encountered when using suxamethonium whilst performing a rapid sequence induction;Secondary Objective: Are there any safety issues associated with the dose of rocuronium which provides equal intubating conditions to those of suxamethonium;Primary end point(s): The primary outcome to be measured is the ‘intubation Conditions score’. We wish to demonstrate which dose of rocuronium provides intubating conditions equal to those with suxamethonium in 9/10 subjects
- Secondary Outcome Measures
Name Time Method