The effect of hydroxychloroquine versus standard drug therapy on the treatment and recurrence of brucellosis
Phase 2
- Conditions
- Brucellosis.Brucellosis
- Registration Number
- IRCT201406299014N37
- Lead Sponsor
- Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- All
- Target Recruitment
- 176
Inclusion Criteria
(a) patients with sign and symptoms of brucellosis have Wright test of more than 1/160 and 2ME titer more than 1/80; (b) patients with chronic brucellosis who did not responded to standard drug therapy with constant or increased 2ME titer; (c) age of 18 years or older.
Exclusion criteria: (a) being pregnant; (b) having history of porphyria, psoriasis, degenerative macula, hemolytic diseases, gastrointestinal diseases, neurologic diseases, and G6PD deficiency.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Response to treatment. Timepoint: before treatment and 1, 2, 3, and 5 months later. Method of measurement: based on 2ME titer.
- Secondary Outcome Measures
Name Time Method Incidence of probable adverse effects such as hepatitis and visual impairment. Timepoint: at 1, 2, 3, and 5 months after treatment. Method of measurement: through history taking and physical examination.