Postoperative Lung Function, Kidney Function, Inflammatory Response and Short-term Outcome After Esophagectomy and Reconstruction: Intraoperative Fluid Management Controlled With Lower and Higher Pulse Pressure Variation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Other Complications of Esophagostomy
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- postoperative lung function, kidney function, inflammatory response
- Status
- Terminated
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.
Detailed Description
Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients undergoing esophagectomy and reconstruction
Exclusion Criteria
- •ASA score \>= 3, (American Society of Anesthesiologist physical status classification system)
- •arrythmia, atrial fibrillation
- •lung diseases, such as COPD (chronic obstructive pulmonary disease); lung function test showed moderate to severe ventilation defect
- •plasma creatinine level above 1.5 mg/dl
Outcomes
Primary Outcomes
postoperative lung function, kidney function, inflammatory response
Time Frame: from introperative to postoperative day 2
plasma creatinine, CRP, lactate, NGAL, IL-6, IL-8
Secondary Outcomes
- postoperative short-term outcome(the duration of hospital stay, about 4 weeks)