NCT01933451终止不适用
Postoperative Lung Function, Kidney Function, Inflammatory Response and Short-term Outcome After Esophagectomy and Reconstruction: Intraoperative Fluid Management Controlled With Lower and Higher Pulse Pressure Variation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- postoperative lung function, kidney function, inflammatory response
研究概览
简要总结
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.
详细描述
Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing esophagectomy and reconstruction
排除标准
- •ASA score >= 3, (American Society of Anesthesiologist physical status classification system)
- •arrythmia, atrial fibrillation
- •lung diseases, such as COPD (chronic obstructive pulmonary disease); lung function test showed moderate to severe ventilation defect
- •plasma creatinine level above 1.5 mg/dl
结局指标
主要结局
postoperative lung function, kidney function, inflammatory response
时间窗: from introperative to postoperative day 2
plasma creatinine, CRP, lactate, NGAL, IL-6, IL-8
次要结局
- postoperative short-term outcome(the duration of hospital stay, about 4 weeks)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
3 期
Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal CancerSurgeryPerioperative CareImmunizationAbdominal NeoplasmsNCT01399814Nanjing PLA General Hospital179
Unknown
不适用
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)Acute Lung Injury (ALI)Acure Respiratory Distress Syndrome (ARDS)SepsisNCT00854386Tel-Aviv Sourasky Medical Center200
招募中
1 期
Effect of intraoperative restrictive fluid therapy versus goal directed fluid therapy on postoperative pulmonary complications in sitting or prone neurosurgical patientsAnaesthesiaPACTR202103623159030Anesthesia department faculty of medicine tanta university70
已完成
不适用
Effect of Intraoperative Fluid Management on MorbidityEpidural AnesthesiaNCT00156338University Hospital Muenster108
已完成
不适用
Restrictive Versus Conservative Fluid Therapy in Colorectal SurgeryFluid TherapyNCT03070080Assiut University60