Musculoskeletal pain in adolescents with Generalized Joint Hypermobility in the context of activity impairment

Completed

Conditions: Ehlers-Danlos (hypermobility type)
Hypermobility Syndrome
10028396

Registration Number: NL-OMON46951

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 75

Inclusion Criteria

Inclusion will be based on one of the following diagnoses:;Hypermobility Syndrome: according to the Brighton criteria
Ehlers Danlos (hypermobility type): Villefranche criteria
Generalized Joint Hypermobility: Beighton score >4

Exclusion Criteria

Primary exclusion criteria encompass the presence of other heritable disorders of connective tissue (HDCT) like Ehlers-Danlos (other than the hypermobile type), Marfan syndrome or osteogenesis imperfecta. If genetic screening rules out HDCT*s, the participant is again eligible for inclusion in the study.;Secondary exclusion criteria encompass:
-A history of surgery is present on the extremities, spine or thorax that could interfere with walking, or with arm/hand function related activities.
-Any conditions that render the participant too unfit to be tested (such as pulmonary and/or cardiac disorders)
-Any conditions that render the participant unable to understand or adhere to the protocol (such as cognitive, social, visual and/or language problems, or hand problems, that render the patient unfit to fill-in the questionnaires).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcomes will be set at the amount of activity impairment. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes will entail potential contributing factors for activity<br /><br>impairment in terms of Musculoskeletal complaints (pain and fatigue), physical<br /><br>factors (Joint biomechanics, muscle power, proprioception) and psychological<br /><br>factors (psychological comorbidity and parental factors).</p><br>