A STUDY COMPARING ORAL ISOTRETNOIN WITH ORAL DOXYCYCLINE AND ADAPALENE 0.1% AND CLINDAMYCIN GEL COMBINATION FOR THE TREATMENT OF SEVERE ACNE VULGARIS

Government Medical College Aurangabad0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•1)Subjects with severe acne vulgaris (IGA at least 4),
•2)weight between 20-110kg
•3) Male or Female subject
•4) Age 10-50 yrs inclusive
•5) Which in the opinion of the investigator is appropriate for treatment with oral isotretinoin (severe nodular acne)

•1)Mild or moderate acne
•2) age <10 and >50 years
•3)deranged liver function tests or any other blood test eg. lipid profile
•4)female who are pregnant, nursing or planning pregnancy during the study
•5)Acne fulminant, acne conglomerate, secondary acne (drug induced etc), pyoderma faciale, sinus tracts, with known metabolic or structural bone disease
•6) subjects with hepatic and renal insufficiency confirmed by blood tests
•7) hypervitaminosis A and/or bowel disease
•8) Subject with a wash-out period from baseline for systemic treatment of less than: corticosteroids, antibiotics (4 weeks), progesterone for contraception (3 months), spironolactone (3 months),other acne treatments (6 months), cyproterone acetate (6 months).
•9) Subject with a wash-out period (from baseline for topical treatment on the face) of less than two weeks (corticosteroids, antibiotics, antibacterials, antiseptics, retinoids, other anti-inflammatory drugs or other acne treatments), one week (cosmetic procedures), three months (photodynamic therapy and laser therapy for acne)
•10) Subject who presents with treated or untreated depression or has a history of depression including a family history of major depression

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