Comparative Evaluation of Oral Doxycycline and Topical Azithromycin in Meibomian Gland Dysfunction Patients

Phase 4

Recruiting

• Conditions: Meibomian gland dysfunction; Doxycycline, Azithromycin&#44

• Registration Number: TCTR20140524001
• Lead Sponsor: Falculty of medicine , Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05-24
• Study Completion: 2015-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

1 Patients age at least 18 years old
2 Patients who are diagnosed meibomian gland dysfunction at least stage 3 by corneal specialist in King Chulalongkorn Memorial Hospital

Exclusion Criteria

1 History of allergic to tetracycline tetracycline derivatives or macrolide
2 History of allergic to fluorescein or tetracaine eye drop
3 Ocular surface inflammation either infection or non infection causes except meibomian gland dysfunction origin at the time of study
4 Punctal occlusion is used at the time of study
5 Pregnancy lactation or preparing for pregnancy either pre study or at the time of study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of patients whose meibum quality improved from level 3 to 1 or 4 to 1-2 4 weeks meibum in each 8 glands in the middle of lower eyelid by meibum expression instrument

Secondary Outcome Measures

Name	Time	Method
Meibum expression 4 weeks counting number from 5 glands of meibomian glands which express meibum by upper or lower eyelid pres,Safety 4 weeks percentage of patients who have side effects from doxycycline and azithromycin,Symptoms 4 weeks 3 symptoms of MGD in discomfort, itching, and photophobia,Tear film stability 4 weeks Averaged tear break up time,Ocular surface staining 4 weeks Calculated via Oxford staining score