The pathophysiology of Deep Vein Thrombosis and Post Thrombotic lesions

Recruiting

• Conditions: deep venous thrombosis; venous thrombo-embolism; 10014523

• Registration Number: NL-OMON53101
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Femoro-popliteal thrombosis, objectively confirmed
- Onset of complaints suggestive of DVT<6 weeks
- Informed consent (IC)

Exclusion Criteria

- - < 18 years
- History of GI bleeding within 12 months
- History of CVA/CNS disease within 12 months
- Severe hypertension (>180/100mmHg)
- Pregnancy
- Previous DVT in the affected leg
- Previous deep venous surgery in the affected leg
- Previous interventions of the superficial venous system <12 months
- Known coagulation disorders
- Surgery within two weeks
- Active malignancy
- Diabetes
- Chronic inflammatory diseases or (auto) immune diseases
- Use of anti-inflammatory medication
- Use of statins
- Allergy to contrast agent (Gadovist)
- Contra-indications for MRI

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcomes are correlations between quantified cell profiles in the thrombus and<br /><br>blood leucocyte profiles of patients in relation to thrombus age and thrombus<br /><br>resolution.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A MRI protocol will be optimised for imaging techniques to gather non-invasive<br /><br>information about thrombus age and resolution.</p><br>