Tissue oxygenation and perfusion and the determination of glucose subcutaneously
Completed
- Conditions
- glucose metabolism1001842410007593
- Registration Number
- NL-OMON34018
- Lead Sponsor
- Onze Lieve Vrouwe Gasthuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Willing and able to give written informed consent
admittance to the OLVG for elective open cardiac surgery (coronary artery bypass graft [CABG]; mitral-, tricuspidal- and aortic valve surgery)
age 18-85 years
Exclusion Criteria
abdominal abnormalities that inhibit sensor insertion
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in glucose values (mmol/l) measured by the two CGMs, Guardian RT and<br /><br>FreeStyle Navigator compared to *gold standard* blood glucose values measured<br /><br>by the Accu-Chek Compact plus (mmol/l), expressed as mean absolute difference<br /><br>(MAD) of glucose values. </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Microcirculatory function expressed as % of perfused vessels as measured by<br /><br>OPS.<br /><br>2. Microcirculatory function expressed as microvascular flow index (MFI) as<br /><br>measured by OPS.<br /><br>3. Tissue oxygen saturation (StO2) expressed as ratio oxygenated haemoglobin to<br /><br>total haemoglobin as measured by near infrared spectroscopy (NIRS).<br /><br>4. Systemic oxygen saturation (SpO2) expressed as % as measured by pulse<br /><br>oximetry.<br /><br>5. APACHE II score.<br /><br>6. SOFA score.<br /><br>7. Glucose values expressed as mmol/l as measured by the Accu-Chek Compact<br /><br>plus. </p><br>